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Effect of Betaine on Reducing Body Fat-A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Abstract
Animal studies have shown the beneficial effect of betaine supplementation on reducing body fat, while the data from human studies are controversial and inconsistent. The objective of the present systematic review was to investigate the effects of betaine intervention on treating obesity in humans and quantitatively evaluate the pooled effects based on randomized controlled trials with a meta-analysis. The PubMed and Scopus databases, and the Cochrane Library, were searched up to September 2019. Weighted mean differences were calculated for net changes in obesity-related indices by using a random-effects model. Publication bias was estimated using Begg's test. Six studies with 195 participants were identified. Betaine supplementation significantly reduced the total body fat mass (-2.53 kg; 95% CI: -3.93, -0.54 kg; I2 = 6.6%, P = 0.36) and body fat percentage (-2.44%; 95% CI: -4.20, -0.68%; I2 = 0.0%, P = 0.44). No changes were observed regarding body weight (-0.29 kg; 95% CI: -1.48, 0.89 kg; I2 = 0.00%, P = 0.99) and body mass index (-0.10 kg/m2; 95% CI: -5.13, 0.31 kg/m2; I2 = 0.00%, P = 0.84). The results suggested that dietary betaine supplementation might be an effective approach for reducing body fat.
AuthorsXiang Gao, Huijun Zhang, Xiao-Fei Guo, Kelei Li, Shan Li, Duo Li
JournalNutrients (Nutrients) Vol. 11 Issue 10 (Oct 16 2019) ISSN: 2072-6643 [Electronic] Switzerland
PMID31623137 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)
Chemical References
  • Anti-Obesity Agents
  • Betaine
Topics
  • Adiposity (drug effects)
  • Adolescent
  • Adult
  • Aged
  • Anti-Obesity Agents (adverse effects, therapeutic use)
  • Betaine (adverse effects, therapeutic use)
  • Body Mass Index
  • Dietary Supplements (adverse effects)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Obesity (diagnosis, drug therapy, physiopathology)
  • Randomized Controlled Trials as Topic
  • Treatment Outcome
  • Weight Loss (drug effects)
  • Young Adult

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