Abstract | INTRODUCTION: METHODS: RESULTS: The prevalence rates of hypertension and hyperlipidemia in neurosyphilis patients were 45.9 and 21.4%, respectively, which were higher than those in patients with other CNS infections (45.9 vs. 28.4%, p = 0.027; 21.4 vs. 8.3%, p = 0.028). In addition, neurosyphilis patients had significantly higher systolic blood pressure (BP; median 139 mm Hg; interquartile range [IQR] 121-151 mm Hg), -diastolic BP (median 83 mm Hg; IQR 76-89 mm Hg), total cholesterol (median 4.86 mmol/L; IQR 3.80-5.51 mmol/L), low-density lipoprotein (median 3.39 mmol/L; IQR 2.52-3.95 mmol/L), and apolipoprotein A1 (apoA1; median 1.31 g/L; IQR 1.06-1.52 g/L) levels and lower apoB/A1 ratios (median 0.67; IQR 0.49-0.99) than patients with other CNS infections (p< 0.05). There were no differences in the DM-related factors between patients with neurosyphilis and those with other CNS infections (p> 0.05). CONCLUSION: Potential association between neurosyphilis and metabolic disorders was found among CNS infections. The results could have important implications for clinical practice, alerting more clinicians to this issue.
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Authors | Yao Xiao, Mei-Jun Chen, Xu Shen, Li-Rong Lin, Li-Li Liu, Tian-Ci Yang, Jian-Jun Niu |
Journal | European neurology
(Eur Neurol)
Vol. 81
Issue 5-6
Pg. 270-277
( 2019)
ISSN: 1421-9913 [Electronic] Switzerland |
PMID | 31618750
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2019 S. Karger AG, Basel. |
Topics |
- Aged
- Central Nervous System Infections
(complications)
- Cross-Sectional Studies
- Diabetes Mellitus
(epidemiology)
- Dyslipidemias
(epidemiology)
- Female
- Humans
- Hypertension
(epidemiology)
- Male
- Middle Aged
- Neurosyphilis
(complications)
- Prevalence
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