Conservative Treatment Possibilities of Ménière Disease, Involving Vertigo Diaries.

Abstract

Ménière disease is a disorder of the inner ear, characterized by rotational vertigo, hearing loss, tinnitus, and vegetative symptoms. The aim of the present research is to examine the effectiveness of betahistine and piracetam in the reduction of vertigo attacks in Ménière disease. To verify our hypothesis, 105 (31 male and 74 females, mean age [standard deviation], 57.4 [11.05]) adult patients with definite Ménière disease were enrolled in this investigation. Beside the analysis of the hospital records, the subjective complaints of the patients and the completed vertigo diaries were taken into consideration too. The statistical analysis was completed using the IBM SPSS version 24 software. Retrospective analysis, including a 12 years period was conducted. Based on our results, betahistine was successful in the reduction of attacks. Statistically significant decrease was achieved in frequency of dizziness (P = .000331) and vertigo (P < .00001) and in the duration of them (P = .000098), although in the mean power of them was not (P = .0887). The mean dose in the symptomatic treatment was determined as 87.5 ± 27.2 mg per day; however, there was no connection detected between the dose of the agent and the effectiveness of the symptomatic control. By using dual therapy (betahistine and piracetam), vertigo episodes appeared significantly less often (P = .027, Odds ratio: 4.9, 95% confidence interval: 1.2-20.2). Finally, it can be concluded that betahistine is effective in Ménière disease, but the daily dose of it should be set up for every patient individually. The advantage of the dual therapy was also confirmed.

• Authors: András Molnár, Stephanie Maihoub, László Tamás, Ágnes Szirmai
• Journal: Ear, nose, & throat journal (Ear Nose Throat J) Vol. 100 Issue 7 Pg. 536-542 (Aug 2021) ISSN: 1942-7522 [Electronic] United States
• PMID: 31617407 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Nootropic Agents
• Betahistine
• Piracetam

Topics

• Betahistine (administration & dosage)
• Conservative Treatment (methods)
• Drug Therapy, Combination
• Female
• Humans
• Male
• Medical Records (statistics & numerical data)
• Meniere Disease (complications, drug therapy)
• Middle Aged
• Nootropic Agents (administration & dosage)
• Odds Ratio
• Piracetam (administration & dosage)
• Retrospective Studies
• Treatment Outcome
• Vertigo (drug therapy, etiology)