Granulomatous
appendicitis is uncommon. It can be caused by infectious or systemic disorders, such as
Crohn's disease (CD) and
sarcoidosis. It is therefore essential to investigate systematic causes of granulomatous
appendicitis after surgery by appropriate examinations. It is also rare for acute appendiceal
inflammation to develop due to active CD. We herein report a case of CD presenting as granulomatous
appendicitis. The patient was a 28-year-old man who arrived at the emergency room with right lower
abdominal pain. Computed tomography showed a low-density lesion with a clear boundary and a small high-density spot in its center behind the cecum. Acute
appendicitis with
abscess formation was suspected and
conservative treatment was started. After 3 consecutive days of
conservative treatment there was no improvement in his condition. We therefore performed open
appendectomy. Histopathological examination showed numerous noncaseous epithelioid
granulomas in the wall of the appendix. Specific staining revealed no evidence of
acid-fast bacilli or fungi. During follow-up after discharge, colonoscopy demonstrated erosion from the cecum to the transverse colon. A colon biopsy showed severe
inflammation with cryptitis, Paneth cells, and a granulomatous lesion. The patient was therefore diagnosed with CD and treatment with
mesalazine was started. Careful examination is necessary to diagnose and properly treat patients with granulomatous
inflammation of the appendix.