Effects of Adipocyte-derived Factors on the Adrenal Cortex.

Abstract

BACKGROUND AND OBJECTIVE:

Obesity is highly complicated by hypertension and hyperglycemia. In particular, it has been proposed that obesity-related hypertension is caused by adipocyte-derived factors that are recognized as undetermined proteins secreted from adipocytes. Adipocyte-derived factors have been known to be related to aldosterone secretion in the adrenal gland. So far, Wnt proteins, CTRP-1, VLDL, LDL, HDL and leptin have been demonstrated to stimulate aldosterone secretion. In contrast, it has not yet been clarified whether adipocyte-derived factors also affect adrenal cortisol secretion.

METHODS AND RESULTS:

In the present study, we investigated the effect of adipocyte-derived factors on cortisol synthase gene CYP11B1 mRNA expression in vitro study using adrenocortical carcinoma H295R cells and mouse fibroblast 3T3-L1cells. Interestingly, adipocyte-derived factors were demonstrated to have the ability to stimulate CYP11B1 mRNA expression.

CONCLUSION:

Since CYP11B1 is well known as a limiting enzyme of cortisol synthesis, our study suggests that adipocyte-derived factors may stimulate cortisol secretion, as well as aldosterone secretion. Taken together, adipocyte-derived factors may be the cause of metabolic syndrome due to their stimulating effects on aldosterone/cortisol secretion. Therefore, the innovation of novel drugs against them may possibly be a new approach against metabolic syndrome.

• Authors: Hiroki Shimada, Erika Noro, Susumu Suzuki, Jun Sakamoto, Ikuko Sato, Rehana Parvin, Atsushi Yokoyama, Akira Sugawara
• Journal: Current molecular pharmacology (Curr Mol Pharmacol) Vol. 13 Issue 1 Pg. 2-6 ( 2020) ISSN: 1874-4702 [Electronic] United Arab Emirates
• PMID: 31613736 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• C1QTNF1 protein, human
• Leptin
• Lipoproteins, LDL
• Proteins
• RNA, Messenger
• Wnt Proteins
• Cytochrome P-450 CYP11B2
• Steroid 11-beta-Hydroxylase
• Hydrocortisone

Topics

• Adipocytes (chemistry)
• Adrenal Cortex (drug effects, metabolism)
• Adrenal Cortex Neoplasms (metabolism, pathology)
• Animals
• Carcinoma (metabolism, pathology)
• Cell Line
• Cell Line, Tumor
• Cytochrome P-450 CYP11B2 (biosynthesis, genetics)
• Fibroblasts
• Gene Expression Regulation (drug effects)
• Humans
• Hydrocortisone (metabolism)
• Leptin (metabolism, pharmacology)
• Lipoproteins, LDL (metabolism, pharmacology)
• Mice
• Proteins (genetics, physiology)
• RNA, Messenger (biosynthesis, genetics)
• Steroid 11-beta-Hydroxylase (biosynthesis, genetics)
• Wnt Proteins (metabolism, pharmacology)
• Zona Fasciculata (drug effects, metabolism)