Effectiveness of Phenolic Antioxidants in Experimental Model of Benign Prostatic Hyperplasia.

Abstract

Experimental model of sulpiride-provoked benign prostatic hyperplasia was employed to comparatively assess the effect of phenolic antioxidants (dihydroquercetin, p-thyrozol, dibornol, and prostagenin) on prostate morphology. All examined agents decreased the degree of hyperplasia in acinar epithelium; the greatest efficacy was demonstrated by prostagenin. Moreover, dihydroquercetin and p-thyrozol increased the cross-section area of acinar lumina and prostate volume, which is inadmissible in this pathology. These results suggest that the use of phenolic antioxidants in the therapy of benign prostatic hyperplasia should be strictly controlled.

• Authors: T G Borovskaya, S I Kamalova, V A Grigor'eva, M E Poluektova, A V Vychuzhanina, A V Kuchin, I Yu Chukicheva, E V Buravlev, T I Fomina, M B Plotnikov, V E Goldberg, A M Dygai
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 167 Issue 5 Pg. 606-609 (Sep 2019) ISSN: 1573-8221 [Electronic] United States
• PMID: 31606803 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Phenols
• Methimazole
• Sulpiride
• Quercetin
• taxifolin

Topics

• Acinar Cells (drug effects, pathology)
• Animals
• Animals, Outbred Strains
• Anti-Inflammatory Agents (pharmacology)
• Antioxidants (pharmacology)
• Disease Models, Animal
• Humans
• Male
• Methimazole (pharmacology)
• Organ Size (drug effects)
• Phenols (pharmacology)
• Prostate (drug effects, pathology)
• Prostatic Hyperplasia (chemically induced, drug therapy, pathology)
• Quercetin (analogs & derivatives, pharmacology)
• Rats
• Sulpiride (administration & dosage)