[Effect of vitamin D supplementation on gestational diabetes mellitus:a Meta-analysis].

Abstract

OBJECTIVE:

This Meta-analysis of randomized controlled trial( RCT) was conducted to summarize the preventive and therapeutic effects of vitamin D supplementation on gestational diabetes mellitus( GDM).

METHODS:

The electronic database( CNKI, CBM, VIP, PubMed, Cochrane library, Web of Science) were systematically searched from inception to February 2018, using the keywords vitamin D and gestational diabetes to identify Meta-analysis.

RESULTS:

A total of 16 RCTs were included. A total of 6 RCTs were included for the prevention of GDM by vitamin D supplementation. Meta-analysis indicated that vitamin D supplementation significantly reduced the level of fasting plasma glucose( FPG)( SMD =-1. 87, 95% CI-3. 39--0. 35) and the incidence of GDM( OR = 0. 42, 95% CI 0. 30-0. 60) in pregnant women. Ten RCTs were included for the treatment of GDM by vitamin D supplementation. Meta-analysis indicated that vitamin D supplementation significantly reduced the level of fasting plasma glucose( FPG)( SMD =-0. 29, 95% CI-0. 56--0. 02) and Fasting Insulin( FINS)( SMD =-0. 42, 95% CI-0. 69--0. 15), also improved the homeostasis model of assessment-estimated insulin resistance( HOMA-IR)( SMD =-0. 53, 95% CI-0. 89--0. 17) and the homeostasis model of assessment-estimated B cell function( HOMA-β)( SMD =-0. 39, 95% CI-0. 61--0. 18), and increased the quantitative insulin sensitivity check index( QUICKI)( SMD = 0. 87, 95% CI 0. 41-1. 32) in GDM patients.

CONCLUSION:

supplementation may prevent and treat GDM by an improvement in HOMA-IR, HOMA-IR and QUICKI.

• Authors: Wanjun Yin, Dan Jin, Mengnan Yao, Wanqi Yu, Peng Zhu
• Journal: Wei sheng yan jiu = Journal of hygiene research (Wei Sheng Yan Jiu) Vol. 48 Issue 5 Pg. 811-821 (Sep 2019) ISSN: 1000-8020 [Print] China
• PMID: 31601326 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Blood Glucose
• Vitamin D

Topics

• Blood Glucose
• Diabetes, Gestational
• Dietary Supplements
• Female
• Humans
• Insulin Resistance
• Pregnancy
• Randomized Controlled Trials as Topic
• Vitamin D