Expression levels of miR-21, miR-146b and miR-326 as potential biomarkers in Behcet's disease.

Abstract

Aim: Behcet's disease (BD) is a vasculitis. Lines of evidence suggest miRNAs as diagnostic and prognostic markers in autoimmune diseases. This study was designed to investigate the potential role of miR-21, miR-146b and miR-326 as biomarkers for diagnosis, predicting organs involvement and measuring BD activity. Patients & methods: In this cross-sectional study, the study groups consisted of 46 BD patients and 70 age- and sex-matched healthy volunteers. The expression rates of three miRNAs were determined by quantitative real-time PCR. Results: Our results demonstrated significantly lower expression of miR-21 and miR-146b and higher expression of miR-326 in BD patients. MiR-21 expression rate in patients with severe eye involvement and miR-326 expression rate in patients with uveitis and severe eye involvement were increased. Conclusion: MiR-326 expression rate can be used as a biomarker for prediction of uveitis and severe eye involvement in patients with BD.

• Authors: Golamreza Jadideslam, Khalil Ansarin, Ebrahim Sakhinia, Zohreh Babaloo, Alireza Abhari, Shahriar Alipour, Jafar Farhadi, Sam S Shirvani, Morteza Ghojazadeh, Alireza Khabbazi
• Journal: Biomarkers in medicine (Biomark Med) Vol. 13 Issue 16 Pg. 1339-1348 (11 2019) ISSN: 1752-0371 [Electronic] England
• PMID: 31599663 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Genetic Markers
• MIRN146 microRNA, human
• MIRN21 microRNA, human
• MIRN326 microRNA, human
• MicroRNAs

Topics

• Adult
• Behcet Syndrome (diagnosis, genetics)
• Female
• Gene Expression Regulation
• Genetic Markers (genetics)
• Humans
• Male
• MicroRNAs (genetics)
• ROC Curve