Discovery of a Novel Cabazitaxel Nanoparticle-Drug Conjugate (CRLX522) with Improved Pharmacokinetic Properties and Anticancer Effects Using a β-Cyclodextrin-PEG Copolymer Based Delivery Platform.
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| Abstract |
Novel nanoparticle-drug conjugates (NDCs) containing diverse, clinically relevant anticancer drug payloads (docetaxel, cabazitaxel, and gemcitabine) were successfully generated and tested in drug discovery studies. The NDCs utilized structurally varied linkers that attached the drug payloads to a β-cyclodextrin-PEG copolymer to form self-assembled nanoparticles. In vitro release studies revealed a diversity of release rates driven by linker structure-activity relationships (SARs). Improved in vivo pharmacokinetics (PK) for the cabazitaxel (CBTX) NDCs with glycinate-containing (1c) and hexanoate-containing linkers (2c) were demonstrated, along with high and sustained tumor levels (>168 h of released drug in tumor tissues). This led to potent efficacy and survival in both taxane- and docetaxel-resistant in vivo anticancer mouse efficacy models. Overall, the CBTX-hexanoate NDC 2c (CRLX522), demonstrated optimal and improved in vivo PK (plasma and tumor) and efficacy profile versus those of the parent drug, and the results support the potential therapeutic use of CRLX522 as a new anticancer agent.
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| Authors | Chester A Metcalf 3rd, Sonke Svenson, Jungyeon Hwang, Snehlata Tripathi, Geeti Gangal, Sujan Kabir, Douglas Lazarus, Roderic Cole, Beata Sweryda-Krawiec, Pochi Shum, Donna Brown, Roy I Case, Derek van der Poll, Ellen Rohde, Stephanie Harlfinger, Chi-Hse Teng, Scott Eliasof |
| Journal | Journal of medicinal chemistry (J Med Chem) Vol. 62 Issue 21 Pg. 9541-9559 (11 14 2019) ISSN: 1520-4804 [Electronic] United States |
| PMID | 31593466 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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