Abstract | BACKGROUND:
Allergy is characterized by allergen-specific IgE production. Molecular-based allergy diagnostic allows to define the precise sensitization profile. Bet v 1 is the major allergen of the PR-10 family. It has been reported that pan- allergens could affect the sensitization panel in adults. OBJECTIVE: This study aimed to evaluate the impact of Bet v 1 sensitization on clinical presentation in a sample of children with Bet v 1-sensitization; oral allergy syndrome (OAS) or anaphylaxis (ANA) were considered. METHODS: Serum IgE molecular components were assessed by ISAC method. Sera and clinical data from 132 children, 91 males (68.94%) and 41 females (31.06%), mean age 9.08 years (3.45 years), were analyzed. RESULTS: Bet v 1-sensitized children were frequently, but not exclusively, sensitized to other molecules belonging to PR-10 family. However, there was no significant difference concerning IgE levels between children with or without food allergy and between children with OAS and ANA, but hazelnut only for generic food allergy. CONCLUSIONS: The present study demonstrates that Bet v 1 sensitization may affect the sensitization pattern in children living in Genoa, a Mediterranean city located in a birch-free area, but it is unable to discriminate patients from a clinical point of view. So, ISAC test should be integrated with more precise IgE assay.
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Authors | Maria Angela Tosca, Michela Silvestri, Angela Pistorio, Roberta Olcese, Paolo Del Barba, Giorgio Ciprandi |
Journal | Acta bio-medica : Atenei Parmensis
(Acta Biomed)
Vol. 90
Issue 3
Pg. 281-286
(09 06 2019)
ISSN: 2531-6745 [Electronic] Italy |
PMID | 31580315
(Publication Type: Journal Article)
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Chemical References |
- Allergens
- Antigens, Plant
- PR-10 protein, walnut birch pollen
- Plant Proteins
- Bet v 1 allergen, Betula
- Immunoglobulin E
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Topics |
- Adolescent
- Allergens
(immunology)
- Anaphylaxis
(immunology)
- Antigens, Plant
(immunology)
- Child
- Child, Preschool
- Female
- Food Hypersensitivity
(immunology)
- Humans
- Immunoglobulin E
(blood)
- Infant
- Infant, Newborn
- Male
- Plant Proteins
(immunology)
- Retrospective Studies
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