[ICG lymphography and fluorescence in pelvic lymphadenectomy for bladder and prostate cancer.]

Abstract

OBJECTIVE:

ICG navigation in cancer surgery may help during pelvic lymphadenectomy.

METHODS:

We performed a systematic review combining the terms: bladder cancer or radical cystectomy and ICG, and prostate cancer or radical prostatectomy and ICG. We used the PRISMA guidelines recommendations. We describe the populations studied in each work, the pathological results, as well as the parameters specificity, sensitivity and predictive values.

RESULTS:

In muscle-invasive bladder cancer, 4 case series analyzed the performance of lymphography with ICG. The most accepted injection method is under endoscopic vision. Several punctures are done in the submucosa and the detrusor surrounding the scar. Sentinel nodes were found in up to 92% of patients with a technique sensitivity to find metastases of 88% in the series with largest casuistry. In prostate cancer, we collected data from 11 case series. Nine of them apply transrectal or transperineal dilution immediately before surgery. Sensitivity in the detection of all adenopathies ranged between 44% and 100%. The sensitivity of the technique to know the lymph node stage ranges between 67% and 100%.

CONCLUSIONS:

There is little experience of ICG-guided lymph node dissedction in bladder tumors. Endoscopic fluorophore injection allows us to find the nodes that drain the infiltrated area. However, the use of this technique is not widespread. In prostate cancer, it is a reproducible and efficient technique for staging patients with prostate cancer.

• Authors: Miguel Ramírez Backhaus, Ana Calatrava-Fons, Álvaro Gómez-Ferrer, Argimiro Collado-Serra, José Luis Domínguez-Escrig, Riccardo Bertolo, José Rubio-Briones
• Journal: Archivos espanoles de urologia (Arch Esp Urol) Vol. 72 Issue 8 Pg. 831-841 (Oct 2019) ISSN: 0004-0614 [Print] Spain
• Vernacular Title: Linfografía con ICG y fluorescencia en la linfadenectomía pélvica por cáncer vesical y prostático.
• PMID: 31579042 (Publication Type: Journal Article, Systematic Review)

Chemical References

• Coloring Agents
• Indocyanine Green

Topics

• Coloring Agents
• Humans
• Indocyanine Green
• Lymph Node Excision
• Lymphatic Metastasis (diagnostic imaging)
• Lymphography
• Male
• Pelvis
• Prostatic Neoplasms (diagnostic imaging, pathology)
• Sentinel Lymph Node Biopsy
• Urinary Bladder Neoplasms (diagnostic imaging, pathology)