Neutropenia and renal dysfunction due to intravesical cidofovir for virus-associated hemorrhagic cystitis after kidney and allogenic hematopoietic stem cell transplantations.

Abstract

We present a patient with virus-associated hemorrhagic cystitis who underwent kidney and allogenic hematopoietic stem cell transplantations (allo-HSCT). Six months post-allo-HSCT, adenovirus hemorrhagic cystitis occurred, which has been in remission after a single dose of intravesical cidofovir. This might cause prolonged neutropenia and nephrotoxicity, suggesting cidofovir absorption in the blood.

• Authors: Takuya Shimizu, Tadakazu Kondo, Kana Matsumoto, Masakatsu Hishizawa, Kouhei Yamashita, Akifumi Takaori-Kondo
• Journal: Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 21 Issue 6 Pg. e13185 (Dec 2019) ISSN: 1399-3062 [Electronic] Denmark
• PMID: 31571390 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2019 Wiley Periodicals, Inc.

Chemical References

• Cidofovir

Topics

• Administration, Intravesical
• Allografts (drug effects, physiopathology)
• Cidofovir (administration & dosage, adverse effects, pharmacokinetics)
• Cystitis (complications, drug therapy, urine, virology)
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Hematuria (drug therapy, urine, virology)
• Humans
• Kidney (drug effects, physiopathology)
• Kidney Transplantation (adverse effects)
• Male
• Middle Aged
• Neutropenia (chemically induced)
• Tissue Distribution
• Transplantation, Homologous (adverse effects)
• Urinary Bladder (drug effects, virology)