Clinical Significance of PRKCI Gene Expression in Cancerous Tissue in Patients With Gastric Cancer.

Abstract

BACKGROUND/AIM:

The PRKCI gene encodes Protein kinase C iota. The overexpression of protein kinase C iota is associated with poor outcomes in patients with gastric and other cancers, but the role of the PRKCI gene in gastric cancer is not fully understood. Thus, we evaluated the clinical significance of PRKCI gene expression in gastric cancer.

MATERIALS AND METHODS:

PRKCI mRNA expression levels in cancerous tissues and adjacent normal mucosa from 398 patients with gastric cancer were measured. Relationships between PRKCI gene expression and clinicopathological characteristics and outcomes were examined.

RESULTS:

Overall survival was lower in patients with a high expression of PRKCI than in those with low expression (p=0.016). No other relationships were observed. A high PRKCI expression was found to be an independent prognostic factor (p=0.036, HR=1.44, 95%CI=1.02-2.02).

CONCLUSION:

PRKCI gene expression in cancerous tissue might be a useful prognostic factor in patients with gastric cancer after gastrectomy.

• Authors: Itaru Hashimoto, Kentaro Sakamaki, Naohide Oue, Yayoi Kimura, Yukihiko Hiroshima, Kentaro Hara, Yukio Maezawa, Kazuki Kano, Toru Aoyama, Takanobu Yamada, Naoto Yamamoto, Takashi Ogata, Hiroyuki Ito, Manabu Shiozawa, Soichiro Morinaga, Yasushi Rino, Wataru Yasui, Munetaka Masuda, Yohei Miyagi, Takashi Oshima
• Journal: Anticancer research (Anticancer Res) Vol. 39 Issue 10 Pg. 5715-5720 (Oct 2019) ISSN: 1791-7530 [Electronic] Greece
• PMID: 31570472 (Publication Type: Journal Article)
• Copyright: Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Isoenzymes
• RNA, Messenger
• Protein Kinase C
• protein kinase C lambda

Topics

• Gastrectomy (methods)
• Gastric Mucosa (pathology)
• Gene Expression (genetics)
• Humans
• Isoenzymes (genetics)
• Prognosis
• Protein Kinase C (genetics)
• RNA, Messenger (genetics)
• Stomach Neoplasms (genetics, pathology)