Inhibition of sodium-glucose cotransporter 2 ameliorates renal injury in a novel medaka model of nonalcoholic steatohepatitis-related kidney disease.

Abstract

The effect of sodium-glucose cotransporter 2 inhibitor (SGLT2I) on nonalcoholic steatohepatitis (NASH) has been reported, but there are few studies on its effect on NASH-related renal injury. In this study, we examined the effect of SGLT2I using a novel medaka fish model of NASH-related kidney disease, which was developed by feeding the d-rR/Tokyo strain a high-fat diet. SGLT2I was administered by dissolving it in water of the feeding tank. SGLT2I ameliorates macrophage accumulation and oxidative stress and maintained mitochondrial function in the kidney. The results demonstrate the effect of SGLT2I on NASH-related renal injury and the usefulness of this novel animal model for research into NASH-related complications.

• Authors: Takuro Nagoya, Kenya Kamimura, Ryo Goto, Yoko Shinagawa-Kobayashi, Yusuke Niwa, Atsushi Kimura, Norihiro Sakai, Masayoshi Ko, Hiroshi Nishina, Shuji Terai
• Journal: FEBS open bio (FEBS Open Bio) Vol. 9 Issue 12 Pg. 2016-2024 (12 2019) ISSN: 2211-5463 [Electronic] England
• PMID: 31561285 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

Chemical References

• Benzhydryl Compounds
• Glucosides
• Glutamate Plasma Membrane Transport Proteins
• Hypoglycemic Agents
• Sodium-Glucose Transporter 2 Inhibitors
• Sodium
• Glucose
• 6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol

Topics

• Animals
• Benzhydryl Compounds (pharmacology)
• Diabetes Mellitus, Type 2
• Diet, High-Fat
• Disease Models, Animal
• Glucose (metabolism)
• Glucosides (pharmacology)
• Glutamate Plasma Membrane Transport Proteins (antagonists & inhibitors, metabolism, physiology)
• Hypoglycemic Agents
• Kidney (pathology)
• Kidney Diseases (metabolism, physiopathology)
• Non-alcoholic Fatty Liver Disease (complications, metabolism)
• Oryzias (metabolism)
• Sodium (metabolism)
• Sodium-Glucose Transporter 2 Inhibitors (pharmacology)