Performance of candidate urinary biomarkers for pancreatic cancer - Correlation with pancreatic cyst malignant progression?

Abstract

BACKGROUND:

Intraductal papillary mucinous neoplasms (IPMN) are precursors of pancreatic cancer. Potential biomarkers of IPMN progression have not been identified in urine. A few urinary biomarkers were reported to be predictive of pancreatic ductal adenocarcinoma (PDAC). Here, we seek to assess their ability to detect high-risk IPMN.

METHODS:

Urine was collected from patients undergoing pancreatic resection and healthy controls. TIMP-1(Tissue Inhibitor of Metalloproteinase-1), LYVE-1(Lymphatic Vessel Endothelial Receptor 1), and PGEM(Prostaglandin E Metabolite) levels were determined by ELISA and analyzed by Kruskal-Wallis.

RESULTS:

Median urinary TIMP-1 levels were significantly lower in healthy controls (n = 9; 0.32 ng/mg creatinine) compared to PDAC (n = 13; 1.95) but not significantly different between low/moderate-grade (n = 20; 0.71) and high-grade/invasive IPMN (n = 20; 1.12). No significant difference in urinary LYVE-1 was detected between IPMN low/moderate (n = 16; 0.37 ng/mg creatinine) and high/invasive grades (n = 21; 0.09). Urinary PGEM levels were not significantly different between groups.

CONCLUSIONS:

Urinary TIMP-1, LYVE-1, and PGEM do not correlate with malignant potential of pancreatic cysts.

• Authors: Michele T Yip-Schneider, Mazhar Soufi, Rosalie A Carr, Katelyn F Flick, Huangbing Wu, Cameron L Colgate, C Max Schmidt
• Journal: American journal of surgery (Am J Surg) Vol. 219 Issue 3 Pg. 492-495 (03 2020) ISSN: 1879-1883 [Electronic] United States
• PMID: 31554598 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers, Tumor
• LYVE1 protein, human
• Prostaglandins E
• TIMP1 protein, human
• Tissue Inhibitor of Metalloproteinase-1
• Vesicular Transport Proteins

Topics

• Adenocarcinoma, Mucinous (surgery, urine)
• Adult
• Aged
• Biomarkers, Tumor (urine)
• Carcinoma, Pancreatic Ductal (surgery, urine)
• Disease Progression
• Female
• Humans
• Male
• Middle Aged
• Pancreatic Cyst (surgery, urine)
• Pancreatic Neoplasms (surgery, urine)
• Prostaglandins E (urine)
• Tissue Inhibitor of Metalloproteinase-1 (urine)
• Vesicular Transport Proteins (urine)