The Gene Polymorphism of Angiotensin-Converting Enzyme Intron Deletion and Angiotensin-Converting Enzyme G2350A in Patients With Left Ventricular Hypertrophy: A Meta-analysis.

Abstract

OBJECTIVES:

The aim of the study was to evaluate the correlation between left ventricular hypertrophy and the gene polymorphism of angiotensin-converting enzyme (ACE) intron deletion (I/D) and ACE G2350A.

METHODS:

Information related to the sample size and genotype frequencies was extracted from each study.

RESULTS:

Our results found that the D allele (p = 0.0180) and DD genotype (p = 0.0110) of ACE I/D had a significant association with increasing the risk of left ventricular hypertrophy, whereas the I allele (p = 0.0180), but not II (p = 0.1660) and ID genotypes (p = 0.1430), was associated with decreasing the risk of left ventricular hypertrophy. On other hand, we found that the A allele (p = 0.0020) and GA genotype of ACE G2350A (p = 0.0070) had the correlation with increasing the risk of left ventricular hypertrophy.

CONCLUSIONS:

Our meta-analysis reveals that the D allele of ACE I/D and the A allele of ACE G2350A are associated with increasing the risk of left ventricular hypertrophy.

• Authors: Jonny Karunia Fajar, Budi Susetio Pikir, Erdo Puncak Sidarta, Putu Nina Berlinda Saka, Rizal Rahmanda Akbar, Teuku Heriansyah
• Journal: Indian heart journal (Indian Heart J) 2019 May - Jun Vol. 71 Issue 3 Pg. 199-206 ISSN: 2213-3763 [Electronic] India
• PMID: 31543192 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)
• Copyright: Copyright © 2019 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

Chemical References

• Peptidyl-Dipeptidase A

Topics

• Humans
• Hypertrophy, Left Ventricular (genetics)
• Introns
• Peptidyl-Dipeptidase A (genetics)
• Polymorphism, Genetic
• Sequence Deletion