Abstract | BACKGROUND: METHODS: HF was induced through partial disruption of the aortic valve in rats. Therapy began 3 hours after valve disruption and lasted 8 weeks. Sacubitril/valsartan (68 mg/kg), valsartan (31 mg/kg), sacubitril (31 mg/kg), or vehicle were administered daily via oral gavage (N=8 in each group). Hemodynamic assessments were conducted using Millar technology, and an exercise tolerance test was conducted using a rodent treadmill. RESULTS: CONCLUSIONS: 1) The synergistic interaction between NEPi and ARB in early therapy with sacubitril/valsartan leads to increased total arterial compliance and EF. 2) Improvement in indices of LV contractility, and exercise tolerance with sacubitril/valsartan is likely because of ARB effect of valsartan. 3) All three therapies provided antifibrotic effects, suggesting both ARB and NEPi are capable of reducing myocardial fibrosis.
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Authors | Mikhail Y Maslov, Stephan Foianini, Dita Mayer, Michael V Orlov, Mark A Lovich |
Journal | Journal of cardiac failure
(J Card Fail)
Vol. 25
Issue 11
Pg. 921-931
(Nov 2019)
ISSN: 1532-8414 [Electronic] United States |
PMID | 31539619
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Elsevier Inc. All rights reserved. |
Chemical References |
- Aminobutyrates
- Angiotensin II Type 1 Receptor Blockers
- Angiotensin Receptor Antagonists
- Biphenyl Compounds
- Drug Combinations
- Tetrazoles
- Valsartan
- sacubitril and valsartan sodium hydrate drug combination
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Topics |
- Aminobutyrates
(administration & dosage, metabolism)
- Angiotensin II Type 1 Receptor Blockers
(administration & dosage, metabolism)
- Angiotensin Receptor Antagonists
(administration & dosage, metabolism)
- Animals
- Aortic Valve Insufficiency
(drug therapy, metabolism)
- Biphenyl Compounds
- Drug Combinations
- Drug Interactions
(physiology)
- Drug Synergism
- Exercise Tolerance
(drug effects, physiology)
- Heart Failure
(drug therapy, metabolism)
- Male
- Rats
- Rats, Sprague-Dawley
- Stroke Volume
(drug effects, physiology)
- Tetrazoles
(administration & dosage, metabolism)
- Valsartan
(administration & dosage, metabolism)
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