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Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1).

Abstract
Verucopeptin is an inhibitor of hypoxia-inducible factor 1 (HIF-1), which is a promising target for cancer chemotherapy. Here, we report the first total synthesis of verucopeptin via condensation of the depsipeptide core and the polyketide side chain unit including three branched methyl groups after the synthesis of each segment.
AuthorsNobuaki Takahashi, Hideaki Hayashi, Viktors Poznaks, Hideaki Kakeya
JournalChemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 55 Issue 79 Pg. 11956-11959 (Oct 01 2019) ISSN: 1364-548X [Electronic] England
PMID31531455 (Publication Type: Journal Article)
Chemical References
  • Alkynes
  • Depsipeptides
  • Hypoxia-Inducible Factor 1
  • Imidazoles
  • Polyketides
  • verucopeptin
  • imidazole
Topics
  • Alkynes (chemistry)
  • Depsipeptides (chemical synthesis, chemistry)
  • Hypoxia-Inducible Factor 1 (antagonists & inhibitors)
  • Imidazoles (chemistry)
  • Molecular Structure
  • Polyketides (chemistry)

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