Abstract | BACKGROUND: METHODS: We thought to examine the perioperative course of these markers in a case series of each three cardiac surgery patients under off-pump cardiac arterial bypass without evolving delirium (OPCAB-NDEL), patients with a procedure under cardio-pulmonary bypass (CPB) without delirium (CPB-NDEL) and delirium after a CPB procedure (CPB-DEL). Delirium was diagnosed by the Confusion Assessment Method for the ICU and chart reviews. RESULTS: We observed increased preoperative levels of tau in patients with later delirium, whereas values of NfL and GFAP did not differ. In the postoperative course, all biomarkers increased multi-fold. NfL levels sharply increased in patients with CPB reaching the highest levels in the CPB-DEL group. CONCLUSION: Tau and NfL might be of benefit to identify patients in cardiac surgery at risk for delirium and to detect patients with the postoperative emergence of delirium.
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Authors | Thomas Saller, Axel Petzold, Henrik Zetterberg, Jens Kuhle, Daniel Chappell, Vera von Dossow, Felix Klawitter, Tobias Schurholz, Christian Hagl, Daniel A Reuter, Bernhard Zwissler, Johannes Ehler |
Journal | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
(Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub)
Vol. 163
Issue 3
Pg. 241-246
(Sep 2019)
ISSN: 1804-7521 [Electronic] Czech Republic |
PMID | 31530945
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Biomarkers
- GFAP protein, human
- Glial Fibrillary Acidic Protein
- Neurofilament Proteins
- tau Proteins
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers
(metabolism)
- Cardiac Surgical Procedures
(adverse effects)
- Delirium
(diagnosis, etiology)
- Female
- Glial Fibrillary Acidic Protein
(metabolism)
- Humans
- Male
- Middle Aged
- Neurofilament Proteins
(metabolism)
- Postoperative Complications
(diagnosis, etiology)
- Prospective Studies
- Retrospective Studies
- Risk Factors
- tau Proteins
(metabolism)
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