Association of Fetuin-B with Subclinical Atherosclerosis in Obese Chinese Adults.

Abstract

AIM:

We aimed to explore the independent associations of serum Fetuin-B and common genetic variants in FETUB locus with subclinical atherosclerosis.

METHODS:

A cross-sectional study of 1,140 obese adults, who underwent serum Fetuin-B testing, hepatic ultrasonography scanning, genotyping on four tagging single nucleotide polymorphisms (SNPs) in FETUB locus and atherosclerosis detection, was conducted in Xiamen, China.

RESULTS:

Increasing tertiles of brachial ankle pulse wave velocity (ba-PWV) were significantly associated with higher prevalence of nonalcoholic fatty liver disease (NAFLD) (48.8%, 61.5%, and 70.5% for tertiles of 1-3, respectively, p＜0.001) and serum Fetuin-B (3.85±1.39, 4.09±1.40, and 4.27±1.46 µg/ml, p=0.047). Multivariable linear regression analyses with adjustment for potential confounding factors, even NAFLD per se, showed that serum Fetuin-B were significantly and positively associated with ba-PWV, with standardized regression coefficients (β) ranging from 0.055 to 0.075 (all p-values ＜0.05) in different models. However, the significant relationship between serum Fetuin-B and ba-PWV disappeared with further adjustment for insulin resistance. Serum Fetuin-B was not significantly associated with ankle-brachial index (ABI). All genotypes of the four tested FETUB tagging SNPs were not significantly associated with either ba-PWV or ABI with adjustment for potential confounding factors.

CONCLUSION:

Serum Fetuin-B was positively associated with ba-PWV and may link liver fat accumulation to subclinical atherosclerosis via insulin resistance.

• Authors: Zhibin Li, Chunmei He, Yongwen Liu, Dongmei Wang, Mingzhu Lin, Changqin Liu, Xiulin Shi, Zheng Chen, Xuejun Li, Shuyu Yang, Weihua Li
• Journal: Journal of atherosclerosis and thrombosis (J Atheroscler Thromb) Vol. 27 Issue 5 Pg. 418-428 (May 01 2020) ISSN: 1880-3873 [Electronic] Japan
• PMID: 31527322 (Publication Type: Journal Article)

Chemical References

• FETUB protein, human
• Fetuin-B

Topics

• Ankle Brachial Index
• Asymptomatic Diseases (epidemiology)
• Atherosclerosis (diagnosis, epidemiology, genetics, physiopathology)
• Cardiometabolic Risk Factors
• Carotid Intima-Media Thickness
• China (epidemiology)
• Cross-Sectional Studies
• Female
• Fetuin-B (analysis, genetics)
• Genetic Predisposition to Disease
• Humans
• Insulin Resistance
• Male
• Middle Aged
• Non-alcoholic Fatty Liver Disease (blood, diagnosis, epidemiology)
• Obesity (blood, diagnosis, epidemiology)
• Polymorphism, Single Nucleotide
• Prevalence