Use of Contemporary Protease Inhibitors and Risk of Incident Chronic Kidney Disease in Persons With Human Immunodeficiency Virus: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study.

Abstract

BACKGROUND:

It is unclear whether use of contemporary protease inhibitors pose a similar risk of chronic kidney disease (CKD) as use of older protease inhibitors.

METHODS:

Participants in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study were followed up until the earliest occurrence of CKD, the last visit plus 6 months, or 1 February 2016. Adjusted Poisson regression was used to assess associations between CKD and the use of ritonavir-boosted atazanavir (ATV/r) or ritonavir-boosted darunavir (DRV/r).

RESULTS:

The incidence of CKD (10.0/1000 person-years of follow-up; 95% confidence interval, 9.5-10.4/1000 person-years of follow-up) increased gradually with increasing exposure to ATV/r, but the relation was less clear for DRV/r. After adjustment, only exposure to ATV/r (adjusted incidence rate ratio, 1.4; 95% confidence interval, 1.2-1.6), but not exposure to DRV/r (1.0; .8-1.3), remained significantly associated with CKD.

CONCLUSION:

While DRV/r use was not significantly associated with CKD an increasing incidence with longer ATV/r use was confirmed.

• Authors: Lene Ryom, Jens Dilling Lundgren, Peter Reiss, Ole Kirk, Matthew Law, Mike Ross, Phillip Morlat, Christoph Andreas Fux, Eric Fontas, Stephane De Wit, Antonella D'Arminio Monforte, Wafaa El-Sadr, Andrew Phillips, Camilla Ingrid Hatleberg, Caroline Sabin, Amanda Mocroft, Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 220 Issue 10 Pg. 1629-1634 (10 08 2019) ISSN: 1537-6613 [Electronic] United States
• PMID: 31504669 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Chemical References

• Anti-HIV Agents
• HIV Protease Inhibitors

Topics

• Adult
• Anti-HIV Agents (adverse effects, therapeutic use)
• Female
• Follow-Up Studies
• HIV Infections (complications, drug therapy)
• HIV Protease Inhibitors (adverse effects, therapeutic use)
• Humans
• Incidence
• Male
• Middle Aged
• Prospective Studies
• Renal Insufficiency, Chronic (chemically induced, epidemiology)
• Risk Assessment