Abstract | INTRODUCTION: METHODS: The CUR loaded micelles were self-assembled by using alendronate- hyaluronic acid- octadecanoic acid (ALN-HA-C18) as an amphiphilic material. The obtained micelles were characterized for size and drug loading. In addition, the in vitro release behavior of CUR was investigated under PBS (pH 5.7) medium containing 1% Tween 80 at 37℃. Furthermore, an hydroxyapatite (the major inorganic component of bone) affinity experiment was studied. In vitro antitumor activity was evaluated. Finally, the anti- tumor efficiency was studied. RESULTS: The size and drug loading of the CUR loaded ALN-HA-C18 micelles were about 118 ± 3.6 nm and 6 ± 1.2%, respectively. CUR was released from the ALN-HA-C18 micelles in a sustained manner after 12 h. The hydroxyapatite affinity experiment indicated that CUR loaded ALN-HA-C18 micelles exhibited a high affinity to bone. CUR loaded ALN-HA-C18 micelles exhibited much higher cytotoxic activity against MG-63 cells compared to free CUR. Finally, CUR loaded ALN-HA-C18 micelles effectively delayed anti- tumor growth properties in osteosarcoma bearing mice as compared with free CUR. CONCLUSION: The present study suggested that ALN-HA-C18 is a novel promising micelle for osteosarcoma targeting and delivery of the hydrophobic anticancer drug CUR.
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Authors | Yanhai Xi, Tingwang Jiang, Yinglan Yu, Jiangmin Yu, Mintao Xue, Ning Xu, Jiankun Wen, Weiheng Wang, Hailong He, Yan Shen, Daquan Chen, Xiaojian Ye, Thomas J Webster |
Journal | International journal of nanomedicine
(Int J Nanomedicine)
Vol. 14
Pg. 6425-6437
( 2019)
ISSN: 1178-2013 [Electronic] New Zealand |
PMID | 31496695
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Drug Carriers
- Micelles
- Polymers
- Stearic Acids
- Hyaluronic Acid
- Curcumin
- Alendronate
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Topics |
- Alendronate
(chemistry, therapeutic use)
- Animals
- Antineoplastic Agents
(therapeutic use)
- Bone Neoplasms
(drug therapy)
- Cell Line, Tumor
- Curcumin
(chemistry, therapeutic use)
- Drug Carriers
(chemistry)
- Drug Delivery Systems
- Drug Liberation
- Humans
- Hyaluronic Acid
(chemistry)
- Male
- Mice, Nude
- Micelles
- Osteosarcoma
(drug therapy, pathology)
- Particle Size
- Polymers
(chemistry)
- Proton Magnetic Resonance Spectroscopy
- Stearic Acids
(chemistry)
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