Effect of tiotropium/olodaterol on sedentary and active time in patients with COPD: post hoc analysis of the VESUTO® study.

Abstract

Background:

Patients with COPD are less physically active. This post hoc analysis of a randomized, double-blind, active-controlled, crossover trial assessed the efficacy of once-daily tiotropium/olodaterol combination therapy versus tiotropium monotherapy in Japanese patients with COPD.

Patients and methods:

Patients were provided with a three-axis accelerometer to measure sedentary and active behavior defined as 1.0-1.5 metabolic equivalents (METs), ≥2.0 METs, and ≥3.0 METs, respectively. Of the 182 patients enrolled, 131 satisfied the conditions for the present analysis and were randomized to tiotropium monotherapy (n=62) or tiotropium/olodaterol combination therapy (n=69).

Results:

Tiotropium/olodaterol combination therapy significantly reduced the duration of 1.0-1.5 MET activity by 8.64 mins (p=0.040) and significantly increased the duration of ≥2.0 MET and ≥3.0 MET activity by 6.51 mins (p=0.017) and 2.60 mins (p=0.008), respectively, compared with tiotropium alone. Subgroup analyses showed that better lung function, milder dyspnea, and higher levels of physical activity at baseline were associated with reduced sedentary time and increased duration of physical activity.

Conclusion:

Tiotropium/olodaterol combination therapy significantly reduced sedentary time and improved physical activity compared with tiotropium monotherapy. This trial was registered in ClinicalTrials.gov (NCT02629965).

• Authors: Yoshiaki Minakata, Takashi Motegi, Jun Ueki, Yasuhiro Gon, Shuhei Nakamura, Tatsuhiko Anzai, Kazuto Hirata, Masakazu Ichinose
• Journal: International journal of chronic obstructive pulmonary disease (Int J Chron Obstruct Pulmon Dis) Vol. 14 Pg. 1789-1801 ( 2019) ISSN: 1178-2005 [Electronic] New Zealand
• PMID: 31496678 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Benzoxazines
• Drug Combinations
• tiotropium-olodaterol
• Tiotropium Bromide

Topics

• Administration, Inhalation
• Aged
• Benzoxazines (administration & dosage)
• Cross-Over Studies
• Double-Blind Method
• Drug Combinations
• Exercise (physiology)
• Female
• Forced Expiratory Volume (drug effects)
• Humans
• Male
• Motor Activity (physiology)
• Nebulizers and Vaporizers
• Pulmonary Disease, Chronic Obstructive (drug therapy, physiopathology)
• Sedentary Behavior
• Tiotropium Bromide (administration & dosage)
• Treatment Outcome