Deregulation of miR-153 has recently been observed in several common human
cancer, while miR-153 serves an oncogene or
tumor suppressive role in different
cancer types. Previously, miR-153 has been identified to be overexpressed in
prostate cancer. miR-153 played an important role in promoting proliferation of human
prostate cancer cells and presented a novel mechanism of
microRNA-mediated direct suppression of
phosphatase and
tensin homolog (PTEN) expression in
prostate cancer cells. Until now, little is known about the clinical significance of miR-153 expression in
prostate cancer.The miR-153 expression in 143 pairs of
prostate cancer and adjacent non-cancerous prostate tissues was measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis. Student t test was conducted for intergroup comparison. Pearson correlation test was used for correlation analysis. Survival curves were carried out by the Kaplan-Meier method and evaluated using the log-rank test. Multivariable Cox proportional hazard risk regression model was performed to screen the independent factor affected the prognosis of
prostate cancer patients.qRT-PCR analysis showed that the expression of miR-153 was significantly increased in the
prostate cancer tissues in comparison with the adjacent noncancerous prostate tissues (P < .001). The high expression of miR-153 in
prostate cancer tissues is closely correlated with aggressive clinical pathological parameters such as
lymph node metastasis (P = .001); bone
metastasis (P < .001); Gleason score (P < .001); and
tumor-node-
metastasis (TNM) stage (P < .001).
Prostate cancer patients with a high expression of miR-153 had an evidently lower 5-year overall survival as compared with those with a low expression of miR-153 (P = .019). Notably, the multivariate Cox regression analysis indicated that miR-153 expression was an independent factor for predicting the 5-year overall survival of
prostate cancer patients (hazard ratio [HR] = 2.481, 95% confidence interval [CI]: 1.582-10.727; P = .018).Our study demonstrated that high miR-153 expression was significantly associated with a poor overall survival independently of other factors in
prostate cancer. Therefore, miR-153 may be an available
biomarker for
prostate cancer prognosis.