Evocalcet: A New Oral Calcimimetic for Dialysis Patients With Secondary Hyperparathyroidism.

Abstract

Patients with chronic kidney disease often develop secondary hyperparathyroidism (SHPT), marked by high levels of circulating parathyroid hormone (PTH) and increased risk of morbidity and mortality. Patients with SHPT are treated with a therapeutic combination that commonly includes calcimimetics, which have recently become popular in clinical settings, and other agents such as vitamin D preparations. Calcimimetics are a drug class that reduces PTH levels by targeting the calcium-sensing receptor. Cinacalcet, a representative calcimimetic, is widely used; however, a high incidence of upper gastrointestinal (GI) tract-related adverse events (AEs) can result in insufficient dosage and poor long-term compliance. The newly approved evocalcet has equivalent efficacy to cinacalcet at a lower clinical dose, with improved bioavailability, fewer upper GI tract-related AEs, and fewer safety concerns. This review gives an overview of calcimimetic agents, with a special focus on evocalcet, and describes the clinical advantages of evocalcet in the treatment of dialysis patients with SHPT.

• Authors: Tadao Akizawa, Kazuaki Ikejiri, Yuichiro Kondo, Yuichi Endo, Masafumi Fukagawa
• Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (Ther Apher Dial) Vol. 24 Issue 3 Pg. 248-257 (Jun 2020) ISSN: 1744-9987 [Electronic] Australia
• PMID: 31486206 (Publication Type: Journal Article, Review)
• Copyright: © 2019 The Authors. Therapeutic Apheresis and Dialysis published by John Wiley & Sons Australia, Ltd on behalf of International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.

Chemical References

• Calcimimetic Agents
• Naphthalenes
• Pyrrolidines
• Receptors, Calcium-Sensing
• evocalcet

Topics

• Calcimimetic Agents (pharmacology)
• Drug Discovery
• Humans
• Hyperparathyroidism, Secondary (drug therapy, etiology)
• Naphthalenes (pharmacology)
• Pyrrolidines (pharmacology)
• Receptors, Calcium-Sensing (antagonists & inhibitors)
• Renal Dialysis (methods)
• Renal Insufficiency, Chronic (complications, metabolism, therapy)
• Treatment Outcome