Abstract | BACKGROUND: METHODS: We will perform a systematic review and meta-analysis of clinical randomized controlled trials to evaluate the efficacy and safety of siponimod in multiple sclerosis. We will search PubMed, EMBASE, Cochrane Library, Clinical Trials, Cochrane Central Register of Controlled Trials (CENTRAL) using a comprehensive strategy. The reference lists of the articles we select for inclusion will be checked to identify additional studies for potential inclusion. Two reviewers will review all literature independently. Upon inclusion of articles, another 2 reviewers will extract available data using a standardized form and assess the potential bias. Review Manager will be used to conduct data synthesis. There is no requirement of ethical approval and informed consent. RESULT: This is the first systematic assessment of siponimod for the treatment of multiple sclerosis. We predict it will provide high-quality synthesis of existing evidence for the efficacy and safety of siponimod for multiple sclerosis and a relatively comprehensive reference for clinical practice and clinical trials about siponimod to be conducted. CONCLUSION: REGISTRATION: The systematic review and meta-analysis is registered in the PROSPERO international prospective register of systematic review (PROSPERO#CRD42018112721).
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Authors | Yumeng Song, Yongfeng Lao, Fuxiang Liang, Jing Li, Bibo Jia, Zixuan Wang, Xu Hui, Zhenxing Lu, Biao Zhou, Wei Luo, Bing Song |
Journal | Medicine
(Medicine (Baltimore))
Vol. 98
Issue 34
Pg. e15415
(Aug 2019)
ISSN: 1536-5964 [Electronic] United States |
PMID | 31441835
(Publication Type: Journal Article)
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Chemical References |
- Azetidines
- Benzyl Compounds
- Immunosuppressive Agents
- siponimod
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Topics |
- Azetidines
(administration & dosage, adverse effects, therapeutic use)
- Benzyl Compounds
(administration & dosage, adverse effects, therapeutic use)
- Dose-Response Relationship, Drug
- Humans
- Immunosuppressive Agents
(administration & dosage, adverse effects, therapeutic use)
- Multiple Sclerosis
(classification, drug therapy)
- Prospective Studies
- Randomized Controlled Trials as Topic
- Research Design
- Meta-Analysis as Topic
- Systematic Review as Topic
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