Abstract |
We examined the antiobesity effect of a limonoid 7-deacetoxy-7-oxogedunin, named CG-1, purified from the seeds of Carapa guianensis, Meliaceae, known as andiroba in high-fat-diet (HFD)-fed mice. C57BL/6 mice were fed a low-fat diet or an HFD and orally administered CG-1 (20 mg/kg) for 7 weeks. CG-1 lowered the body weight gain and improved the serum triglyceride level and insulin sensitivity in HFD-fed mice. The expression level of the adipogenesis-related genes was lowered by CG-1 in the visceral white adipose tissue (vWAT). The mRNA expression level of the macrophage-related genes decreased in vWAT following the administration of CG-1 to HFD-fed mice. It is noteworthy that CG-1 activated the brown adipose tissue (BAT) with enhanced expression of uncoupling protein 1 and increased the rectal temperature in HFD-fed mice. These results indicate that the limonoid CG-1 decreased body weight gain and ameliorated hypertriglyceridemia and insulin resistance with the activation of BAT in HFD-fed mice.
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Authors | Chihiro Matsumoto, Toko Maehara, Reiko Tanaka, Ko Fujimori |
Journal | Journal of agricultural and food chemistry
(J Agric Food Chem)
Vol. 67
Issue 36
Pg. 10107-10115
(Sep 11 2019)
ISSN: 1520-5118 [Electronic] United States |
PMID | 31434473
(Publication Type: Journal Article)
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Chemical References |
- Anti-Obesity Agents
- Limonins
- Plant Extracts
- Triglycerides
- Uncoupling Protein 1
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Topics |
- Adipose Tissue, Brown
(drug effects, metabolism)
- Animals
- Anti-Obesity Agents
(administration & dosage)
- Diet, High-Fat
(adverse effects)
- Humans
- Insulin Resistance
- Limonins
(administration & dosage)
- Male
- Meliaceae
(chemistry)
- Mice
- Mice, Inbred C57BL
- Obesity
(drug therapy, genetics, metabolism, physiopathology)
- Plant Extracts
(administration & dosage)
- Seeds
(chemistry)
- Triglycerides
(blood)
- Uncoupling Protein 1
(genetics, metabolism)
- Weight Gain
(drug effects)
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