Topical 5-aminolevulinic acid photodynamic therapy for laryngeal papillomatosistosis treatment.

Abstract

BACKGROUND:

To explore the therapeutic effect of topical 5-Aminolevulinic Acid photodynamic therapy (ALA-PDT) on laryngeal papillomatosis (LP) treatment.

METHODS:

13 patients with LP underwent topical ALA-PDT after tumor resection (CO2laser or/and microdebrider resection). All patients were irradiated 3-4 times. After ALA-PDT treatment, the laryngoscopic examination was performed every 1-2 months to observe the therapeutic effect.

RESULTS:

All 13 patients were followed up for more than 1 year. Eleven cases (84.6%) showed no recurrence; two cases (15.4%) had relapses. One child developed III° inspiratory dyspnea caused by laryngeal mucosal edema and need endotracheal intubation again. Four patients had adhesion of the anterior commissure of the vocal cord. The detection rate of HPV infections was 76.9% and two patients had multiple HPV subtype co-infection.

CONCLUSIONS:

The preliminary effect of topical ALA-PDT significantly reduces recurrence and improves the cure rate of LP. Further research on this treatment is still required.

• Authors: Faya Liang, Pin Han, Renhui Chen, Peiliang Lin, Mingrui Luo, Qian Cai, Xiaoming Huang
• Journal: Photodiagnosis and photodynamic therapy (Photodiagnosis Photodyn Ther) Vol. 28 Pg. 136-141 (Dec 2019) ISSN: 1873-1597 [Electronic] Netherlands
• PMID: 31430574 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• Photosensitizing Agents
• Aminolevulinic Acid

Topics

• Administration, Topical
• Adult
• Aminolevulinic Acid (administration & dosage)
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Laryngeal Neoplasms (drug therapy, surgery, virology)
• Laryngoscopy
• Male
• Neoplasm Recurrence, Local (prevention & control)
• Papilloma (drug therapy, surgery, virology)
• Papillomavirus Infections (drug therapy, surgery)
• Photochemotherapy (methods)
• Photosensitizing Agents (administration & dosage)