It is well known that emotions can interfere with the perception of physical
pain, as well as with the development and maintenance of painful conditions. On the other hand,
somatic pain can have significant consequences on an individual's affective behavior. Indeed,
pain is defined as a complex and multidimensional experience, which includes both sensory and emotional components, thus exhibiting the features of a highly subjective experience. Over the years, neural pathways involved in the modulation of the different components of
pain have been identified, indicating the existence of medial and lateral
pain systems, which, respectively, project from medial or lateral thalamic nuclei to reach distinct cortex regions relating to specific functions. However, owing to the limited information concerning how mood state and painful input affect each other,
pain treatment is frequently unsatisfactory. Different
neuromodulators, including endogenous
neuropeptides, appear to be involved in
pain-related emotion and in its affective influence on pain perception, thus playing key roles in vulnerability and clinical outcome. Hence, this review article focuses on evidence concerning the modulation of the sensory and affective dimensions of
pain, with particular attention given to some selected neuropeptidergic system contributions.