Risk of Zika microcephaly correlates with features of maternal antibodies.

Abstract

Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015-2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.

• Authors: Davide F Robbiani, Priscilla C Olsen, Federico Costa, Qiao Wang, Thiago Y Oliveira, Nivison Nery Jr, Adeolu Aromolaran, Mateus S do Rosário, Gielson A Sacramento, Jaqueline S Cruz, Ricardo Khouri, Elsio A Wunder Jr, Adriana Mattos, Bruno de Paula Freitas, Manoel Sarno, Gracinda Archanjo, Dina Daltro, Gustavo B S Carvalho, Kleber Pimentel, Isadora C de Siqueira, João R M de Almeida, Daniele F Henriques, Juliana A Lima, Pedro F C Vasconcelos, Dennis Schaefer-Babajew, Stephanie A Azzopardi, Leonia Bozzacco, Anna Gazumyan, Rubens Belfort Jr, Ana P Alcântara, Gustavo Carvalho, Licia Moreira, Katiaci Araujo, Mitermayer G Reis, Rebekah I Keesler, Lark L Coffey, Jennifer Tisoncik-Go, Michael Gale Jr, Lakshmi Rajagopal, Kristina M Adams Waldorf, Dawn M Dudley, Heather A Simmons, Andres Mejia, David H O'Connor, Rosemary J Steinbach, Nicole Haese, Jessica Smith, Anne Lewis, Lois Colgin, Victoria Roberts, Antonio Frias, Meredith Kelleher, Alec Hirsch, Daniel N Streblow, Charles M Rice, Margaret R MacDonald, Antonio R P de Almeida, Koen K A Van Rompay, Albert I Ko, Michel C Nussenzweig
• Journal: The Journal of experimental medicine (J Exp Med) Vol. 216 Issue 10 Pg. 2302-2315 (10 07 2019) ISSN: 1540-9538 [Electronic] United States
• PMID: 31413072 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 Robbiani et al.

Chemical References

• Antibodies, Viral

Topics

• Animals
• Antibodies, Viral (immunology)
• Brain (embryology, immunology, pathology)
• Female
• Fetus (embryology, immunology, pathology)
• Humans
• K562 Cells
• Macaca mulatta
• Macaca nemestrina
• Maternal-Fetal Exchange (immunology)
• Microcephaly (immunology, pathology)
• Pregnancy
• Pregnancy Complications, Infectious (immunology, pathology)
• Zika Virus (immunology)
• Zika Virus Infection (immunology, pathology)