Two-hour postload plasma glucose and pigment epithelium-derived factor levels are markers of coronary artery inflammation in type 2 diabetic patients.

Abstract

BACKGROUND:

We have previously found that pioglitazone attenuates inflammation in the left main trunk of coronary artery (LMT), evaluated as target-to-background ratio (TBR) by 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in patients with impaired glucose tolerance or type 2 diabetes.

OBJECTIVES:

We assessed which clinical variables could predict the change in TBR in the LMT after 4-month add-on therapy with oral hypoglycemic agents (OHAs).

METHODS:

A total of 38 type 2 diabetic patients with carotid atherosclerosis who had already received OHAs except for pioglitazone was enrolled. At baseline and 4 months after add-on therapy with pioglitazone or glimepiride, all patients underwent 75 g oral glucose tolerance test, blood chemistry analysis, and FDG-PET/CT.

RESULTS:

Fasting plasma glucose, 30-, 60-, 90-, 120-minutes postload plasma glucose, HbA1c, and LMT-TBR values were significantly decreased by add-on therapy, whereas high-density lipoprotein-cholesterol and adiponectin levels were increased. Increased serum levels of pigment epithelium-derived factor (PEDF), a marker of insulin resistance and non-use of aspirin at baseline could predict the favorable response of LMT-TBR to add-on therapy. Moreover, Δ120-minutes postload plasma glucose and ΔPEDF were independent correlates of ΔLMT-TBR.

CONCLUSIONS:

Our present study suggests that 120-minutes postload plasma glucose and PEDF values may be markers and potential therapeutic targets of coronary artery inflammation in type 2 diabetic patients.

CLINICAL TRIAL REGISTRATION:

URL: http://clinicaltrials.gov . Unique identifier: NCT00722631. New markers for diabetes and CAD is on the horizon! Two-hour postload plasma glucose and pigment epithelium derived factor are markers of coronary artery inflammation in type 2 diabetic patients.

• Authors: Nobuhiro Tahara, Yoshikazu Nitta, Munehisa Bekki, Atsuko Tahara, Shoko Maeda-Ogata, Yoichi Sugiyama, Akihiro Honda, Sachiyo Igata, Tomohisa Nakamura, Jiahui Sun, Seiji Kurata, Kiminori Fujimoto, Toshi Abe, Takanori Matsui, Sho-Ichi Yamagishi, Yoshihiro Fukumoto
• Journal: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (J Nucl Cardiol) Vol. 27 Issue 4 Pg. 1352-1364 (08 2020) ISSN: 1532-6551 [Electronic] United States
• PMID: 31407236 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Blood Glucose
• Eye Proteins
• Nerve Growth Factors
• Serpins
• pigment epithelium-derived factor

Topics

• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Blood Glucose (analysis)
• Coronary Artery Disease (blood, diagnosis)
• Diabetes Mellitus, Type 2 (blood, complications)
• Diabetic Angiopathies (blood, diagnosis)
• Eye Proteins (blood)
• Female
• Humans
• Inflammation (blood, diagnosis)
• Male
• Middle Aged
• Nerve Growth Factors (blood)
• Serpins (blood)