5-oxoprolinuria (Pyroglutamic Aciduria) and Metabolic Acidosis: Unraveling the Mystery.

Abstract

A case of high anion gap metabolic acidosis (HAGMA) and high level of 5-oxoprolinuria were noticed in an elderly female of 66 years who had multiple risk/precipitating factors and recovered well with N-acetyl cysteine infusion. This is reported in view of its rarity and to create awareness of this entity among medical students and practicing physicians who handles such cases in emergency room or critical care unit. Moreover they have to remember and investigate the cases of metabolic acidosis for 5-oxoprolinuia especially in susceptible individuals who are on paracetamol with or without other precipitating factors.

HOW TO CITE THIS ARTICLE:

Senthilkumaran S, Benita F, Jena NN, Sasikumar S, Thirumalaikolundusubramanian P. 5-oxoprolinuria (Pyroglutamic Aciduria) and Metabolic Acidosis: Unraveling the Mystery. Indian J Crit Care Med 2019;23(7):342-343.

• Authors: Subramanian Senthilkumaran, Florence Benita, Narendra Nath Jena, Sambathkumar Sasikumar, Ponniah Thirumalaikolundusubramanian
• Journal: Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine (Indian J Crit Care Med) Vol. 23 Issue 7 Pg. 342-343 (Jul 2019) ISSN: 0972-5229 [Print] India
• PMID: 31406447 (Publication Type: Case Reports)