Identification and localization of the apoprotein fraction of the bile lipoprotein complex in human gallstones.

Abstract	The anionic polypeptidic fraction is the protein constituent of the bile lipoprotein complex. Double immunodiffusion and sodium dodecyl sulfate polyacrylamide gel electrophoresis studies show that the anionic polypeptidic fraction is present in human gallstones. In terms of weight percentage, this protein accounts for 0.1% +/- 0.087 (n = 6) of the total weight of gallstones. Immunolocalization studies confirm the presence of the anionic polypeptidic fraction in human gallstones and suggest that this protein is preferentially associated with pigmented layers in gallstones. A speculative role for the anionic polypeptidic fraction in cholesterol nucleation is discussed.
Authors	M Martigne, N Domingo, P Lechêne de la Porte, H Lafont, J Hauton
Journal	Scandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 23 Issue 6 Pg. 731-7 (Aug 1988) ISSN: 0036-5521 [Print] England
PMID	3140369 (Publication Type: Journal Article)
Chemical References	Amino Acids Apoproteins Lipoproteins
Topics	Amino Acids (analysis) Apoproteins (analysis) Bile (analysis) Cholelithiasis (analysis, pathology) Enzyme-Linked Immunosorbent Assay Humans Immunodiffusion Lipoproteins (analysis)

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