Abstract | BACKGROUND:
Candidalysin is a cytolytic peptide toxin secreted by Candida albicans hyphae and has significantly advanced our understanding of fungal pathogenesis. Candidalysin is critical for mucosal C albicans infections and is known to activate epithelial cells to induce downstream innate immune responses that are associated with protection or immunopathology during oral or vaginal infections. Furthermore, candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. However, the role of candidalysin in driving systemic infections is unknown. METHODS: RESULTS:
Candidalysin induces immune activation and neutrophil recruitment in vivo, and it promotes mortality in zebrafish and murine models of systemic fungal infection. CONCLUSIONS: The data demonstrate a key role for candidalysin in neutrophil recruitment and fungal virulence during disseminated systemic C albicans infections.
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Authors | Marc Swidergall, Mina Khalaji, Norma V Solis, David L Moyes, Rebecca A Drummond, Bernhard Hube, Michail S Lionakis, Craig Murdoch, Scott G Filler, Julian R Naglik |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 220
Issue 9
Pg. 1477-1488
(09 26 2019)
ISSN: 1537-6613 [Electronic] United States |
PMID | 31401652
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. |
Chemical References |
- Cytokines
- ECE1 protein, Candida albicans
- Fungal Proteins
- Virulence Factors
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Topics |
- Animals
- Candida albicans
(growth & development, immunology, metabolism)
- Candidiasis, Invasive
(microbiology, pathology)
- Cytokines
(metabolism)
- Disease Models, Animal
- Endothelial Cells
(drug effects, immunology, metabolism)
- Female
- Fungal Proteins
(metabolism)
- Male
- Mice, Inbred BALB C
- Neutrophil Infiltration
- Signal Transduction
- Survival Analysis
- Virulence
- Virulence Factors
(metabolism)
- Zebrafish
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