Abstract | BACKGROUND: METHODS: A systematic review and pooled analysis was conducted to summarize available evidence for HBO2 in mTBI-associated PCS ± PTSD. Data aggregated from four Department of Defense (DoD) studies with participant-level data (n=254) were grouped into pooled HBO2 and sham intervention groups. Changes from baseline to post-intervention on PCS, PTSD, and neuropsychological measures were assessed using linear mixed models to evaluate main intervention and intervention-by-baseline PTSD effects. Potential dose-response relationships to oxygen partial pressures were investigated. Intervention effects from three other published studies with summary-level participant data (n=135) were also summarized.. RESULTS: Pooled DoD data analyses indicated trends toward improvement favoring HBO2 for PCS (Rivermead Total Score: -2.3, 95% CI [-5.6, 1.0], p=0.18); PTSD ( PTSD Checklist Total Score: -2.7, 95% CI [-5.8, 0.4], p=0.09); and significant improvement in verbal memory (CVLT-II Trial 1-5 Free Recall: 3.8; 95% CI [1.0, 6.7], p=0.01). A dose-response trend to increasing oxygen partial pressure was also found, with a greater HBO2 effect in mTBI-associated PTSD suggested. The direction of results was consistent with other published studies. CONCLUSION: A definitive clinical trial, with an appropriate control group, should be considered to identify the optimal HBO2 dosing regimen for individuals with mTBI-associated PTSD ± PCS.
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Authors | Brett B Hart, Lindell K Weaver, Ashutosh Gupta, Steffanie H Wilson, Amarnath Vijayarangan, Kayla Deru, Donald Hebert |
Journal | Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
(Undersea Hyperb Med)
2019 BIMA Special Edition No. Feb
Vol. 46
Issue 3
Pg. 353-383
ISSN: 1066-2936 [Print] United States |
PMID | 31394604
(Publication Type: Journal Article, Systematic Review)
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Copyright | Copyright© Undersea and Hyperbaric Medical Society. |
Chemical References |
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Topics |
- Adult
- Brain Concussion
(complications)
- Checklist
- Female
- Humans
- Hyperbaric Oxygenation
- Linear Models
- Male
- Memory
- Mental Recall
- Middle Aged
- Military Personnel
- Neuropsychological Tests
- Oxygen
- Partial Pressure
- Post-Concussion Syndrome
(complications, therapy)
- Quality of Life
- Sensitivity and Specificity
- Stress Disorders, Post-Traumatic
(complications, therapy)
- Treatment Outcome
- United States
- United States Department of Defense
- Young Adult
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