Allergic contact dermatitis caused by 1,6-hexanediol diacrylate in a hospital wristband.

Abstract

BACKGROUND:

1,6-Hexanediol diacrylate (1,6-HDDA) is a multifunctional acrylate and a potent sensitizer.

OBJECTIVES:

To report a case of allergic contact dermatitis caused by 1,6-HDDA in a hospital wristband.

METHODS:

A male patient presented with eczema on his wrist where he had worn a hospital wristband. Patch testing was performed with our extended European baseline series, additional series, and pieces of the hospital wristband. Thin-layer chromatography (TLC) was performed with extracts from the wristband and gas chromatography-mass spectrometry was used for chemical analysis.

RESULTS:

Positive reactions were found to pieces of the wristband, including adhesive rim (+++), inside (+++), and outside (++); to multiple allergens in the (meth)acrylates series; and to extracts of the wristband in acetone and ethanol. Chemical analysis of the ethanol extract showed presence of lauryl acrylate and 1,6-HDDA. Patch testing with TLC strips and subsequent chemical analysis showed that the substance causing the strongest reaction was 1,6-HDDA, to which the patient had a confirmed positive patch test reaction.

CONCLUSION:

1,6-HDDA was identified as the culprit allergen responsible for allergic contact dermatitis caused by the hospital wristband.

• Authors: Cynthia C A van Amerongen, Jakob Dahlin, Marléne Isaksson, Marie L A Schuttelaar
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 81 Issue 6 Pg. 446-449 (Dec 2019) ISSN: 1600-0536 [Electronic] England
• PMID: 31392731 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2019 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.

Chemical References

• Acrylates
• 1,6-hexanediol diacrylate

Topics

• Acrylates (adverse effects)
• Aged
• Dermatitis, Allergic Contact (etiology)
• Hospitals
• Humans
• Male
• Patch Tests
• Patient Identification Systems
• Wrist