Abstract | PURPOSE: METHODS: We enrolled 104 patients with thoracic ESCC, who underwent curative esophagectomy. RESULTS: Receiver operating curve analyses indicated that the optimal cut-off values of pre- and postoperative PDW were 16.9 and 17.0, respectively. The 5-year overall survival (OS) rate was significantly lower in patients with a high-preoperative PDW (≥ 16.9; 52.6%) than in those with a low-preoperative PDW (< 16.9; 61.0% P = 0.045). The 5-year disease-specific survival (DSS) rates were 64.3% in patients with a high-preoperative PDW and 69.3% in those with a low-preoperative PDW (P = 0.13). Regarding the postoperative PDW, the 5-year OS rate was significantly lower in patients with a high-postoperative PDW (≥ 17.0; 35.7%) than in those with a low-postoperative PDW (< 17.0; 66.8% P = 0.0017). The 5-year DSS rates were 52.2% in patients with a high-postoperative PDW and 73.2% in those with a low-postoperative PDW (P = 0.037). Finally, a multivariate analysis revealed that the postoperative PDW but not the preoperative PDW was an independent prognostic factor. CONCLUSIONS: The postoperative PDW was useful for predicting the prognosis of patients with ESCC.
|
Authors | Tomoyuki Matsunaga, Hiroaki Saito, Yoji Fukumoto, Shota Shimizu, Yusuke Kono, Yuki Murakami, Yuji Shishido, Kozo Miyatani, Manabu Yamamoto, Naruo Tokuyasu, Shuichi Takano, Teruhisa Sakamoto, Soichiro Honjo, Yoshiyuki Fujiwara |
Journal | Surgery today
(Surg Today)
Vol. 50
Issue 2
Pg. 123-133
(Feb 2020)
ISSN: 1436-2813 [Electronic] Japan |
PMID | 31388825
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Biomarkers
(blood)
- Blood Platelets
- Carcinoma, Squamous Cell
(diagnosis, mortality)
- Esophageal Neoplasms
(diagnosis, mortality)
- Forecasting
- Humans
- Postoperative Period
- Prognosis
- Survival Rate
|