Heterogeneity of latent tuberculosis infection in a patient with lung cancer.

Abstract

Latent tuberculosis infection may become a source of tuberculosis dissemination, even in a subclinical case, which have no abnormalities in the pulmonary parenchyma based on imaging studies. In this case, we presented tiny granulomas beside squamous cell carcinoma in a woman positive for interferon-γ release assay (IGRA). She had no symptoms or abnormalities in the parenchyma, except for the primary lesion. Mycobacterium tuberculosis was cultured from the mediastinal lymph nodes in concurrence with [18F] fluoro-deoxy glucose uptake. The findings of the present study stress the need for careful attention to the development of tuberculosis in case of a positive IGRA.

• Authors: Fumihiro Yamaguchi, Takao Minakata, Sakiko Miura, Takashi Suzuki, Hironori Sagara
• Journal: Journal of infection and public health (J Infect Public Health) Vol. 13 Issue 1 Pg. 151-153 (Jan 2020) ISSN: 1876-035X [Electronic] England
• PMID: 31383566 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

Topics

• Aged
• Carcinoma, Squamous Cell (diagnosis)
• Disease Progression
• Female
• Granuloma (microbiology)
• Humans
• Interferon-gamma Release Tests
• Latent Tuberculosis (diagnosis, microbiology)
• Lung (diagnostic imaging, pathology)
• Lung Neoplasms (complications, microbiology)
• Lymph Nodes (microbiology, pathology)
• Mycobacterium tuberculosis (isolation & purification)
• Tomography, X-Ray Computed