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How to obtain severe hypoglycemia without causing brain or cardiac damage.

Abstract
Cancer is the second cause of death worldwide, but current therapies are often insufficient or linked with toxicity. Initial evidence in scientific literature seems to support the role of non-pharmacological strategies, including hypoglycemia, in cancer treatment. The biological rationale for hypoglycemia-based treatment of cancer resides in the evidence that cancer cells predominantly utilize glucose as an energy source; notably, cancer cells seem to have damaged glycolysis regulation and few, defective mitochondria showing impaired oxidative phosphorylation. Preliminary data arising from both preclinical and human studies support the role of hypoglycemia in inducing apoptosis on cancer cells. In this paper, we describe how to induce and maintain severe hypoglycemia without causing damage to either the brain or the heart. Our hypothesis is that ExtraCorporeal Membrane Oxygenation (ECMO) and selective glucose perfusion of the carotid vessels are able to maintain severe hypoglycemia without causing cardiac or brain damage. This will allow physicians to study the effect of severe hypoglycemia on cancer cell apoptosis in vivo.
AuthorsMartina Baiardo Redaelli, Alberto Zangrillo, Vanesa Gregorc, Fabio Ciceri, Lorenzo Dagna, Yamume Tshomba, Paolo Navalesi, Giovanni Landoni
JournalMedical hypotheses (Med Hypotheses) Vol. 130 Pg. 109276 (Sep 2019) ISSN: 1532-2777 [Electronic] United States
PMID31383320 (Publication Type: Journal Article)
CopyrightCopyright © 2019 Elsevier Ltd. All rights reserved.
Chemical References
  • Blood Glucose
  • Glucose
Topics
  • Animals
  • Apoptosis
  • Blood Glucose (analysis)
  • Brain (metabolism)
  • Brain Injuries (prevention & control)
  • Carotid Arteries (physiopathology)
  • Extracorporeal Membrane Oxygenation
  • Glucose (metabolism)
  • Glycolysis
  • Heart Diseases (prevention & control)
  • Humans
  • Hypoglycemia (physiopathology)
  • Mitochondria (metabolism)
  • Models, Theoretical
  • Neoplasms (physiopathology, therapy)
  • Oxidative Phosphorylation
  • Patient Safety
  • Perfusion

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