Hyaluronic Acid Grafted Nanoparticles of a Platinum(II)-Silicon(IV) Phthalocyanine Conjugate for Tumor and Mitochondria-Targeted Photodynamic Therapy in Red Light.

Abstract

Herein, we report novel hyaluronic acid formulated nanoparticles containing a platinum(II) conjugated silicon(IV) phthalocyanine (SiPc-Pt-HA) for tumor targeted red light photodynamic therapy and chemotherapy. The SiPc-Pt-HA conjugate showed specific uptake, photo-enhanced cytotoxicity (~1500 fold) and mitochondrial accumulation in breast cancer over normal cells.

• Authors: Koushambi Mitra, Montserrat Samso, Charles E Lyons, Matthew C T Hartman
• Journal: Journal of materials chemistry. B (J Mater Chem B) Vol. 6 Issue 45 Pg. 7373-7377 (12 07 2018) ISSN: 2050-7518 [Electronic] England
• PMID: 31372221 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Antineoplastic Agents
• CD44 protein, human
• Hyaluronan Receptors
• Indoles
• Isoindoles
• Photosensitizing Agents
• Platinum
• Hyaluronic Acid
• phthalocyanine
• Silicon

Topics

• Antineoplastic Agents (chemistry, pharmacology, radiation effects)
• Apoptosis (drug effects)
• Cell Line, Tumor
• HEK293 Cells
• Humans
• Hyaluronan Receptors (metabolism)
• Hyaluronic Acid (chemistry, radiation effects)
• Indoles (chemistry, pharmacology, radiation effects)
• Isoindoles
• Light
• Mitochondria (metabolism)
• Nanoparticles (chemistry, radiation effects)
• Photochemotherapy (methods)
• Photosensitizing Agents (chemistry, pharmacology, radiation effects)
• Platinum (chemistry)
• Silicon (chemistry)