The Medical Therapy of Craniopharyngiomas: The Way Ahead.

Abstract

CONTEXT:

Craniopharyngiomas, which are categorized as adamantinomatous (ACPs) or papillary (PCPs), have traditionally been treated with surgery and/or radiotherapy, although when the tumors progress or recur, therapeutic possibilities are very limited. Following recent advances in their molecular pathogenesis, new medical therapeutic options have emerged.

EVIDENCE ACQUISITION:

The search strategy that we selected to identify the appropriate evidence involved the following medical subject headings (MeSH) terms: ("Craniopharyngioma" [MeSH] AND "Craniopharyngioma/drug therapy" [MeSH]) NOT ("review" [Publication Type] OR "review literature as topic" [MeSH Terms] OR "review" [All Fields]) AND ("2009/05/01" [PDat]: "2019/04/28" [PDat]).

EVIDENCE SYNTHESIS:

Mutations of β-catenin causing Wnt activation with alterations of the MEK/ERK pathway are encountered in the great majority of patients with ACPs; specific alterations also stratify patients to a more aggressive behavior. In most PCPs there is primary activation of the Ras/Raf/MEK/ERK pathway secondary to BRAF-V600E mutations. BRAF inhibitors, such as dabrafenib or vemurafenib, either alone or in combination with the MEK inhibitors trametinib and cobimetinib, have been administered to patients with PCPs producing clinically useful and, in some cases, sustained responses. In contrast to PCPs, drugs targeting β-catenin and its downstream MAPK pathway in ACPs have so far only been used in in vitro studies, but there appear to be promising new targets clinically.

CONCLUSIONS:

The identification of specific genetic alterations in patients with craniopharyngiomas has expanded the therapeutic options, providing evidence for a customized approach using newer molecular agents. More studies including a larger number of carefully selected patients are required to evaluate the response to currently available and evolving agents alone and in combination.

• Authors: Krystallenia I Alexandraki, Gregory A Kaltsas, Niki Karavitaki, Ashley B Grossman
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 104 Issue 12 Pg. 5751-5764 (12 01 2019) ISSN: 1945-7197 [Electronic] United States
• PMID: 31369091 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2019 Endocrine Society.

Chemical References

• Antineoplastic Agents
• Protein Kinase Inhibitors
• beta Catenin
• BRAF protein, human
• Proto-Oncogene Proteins B-raf

Topics

• Antineoplastic Agents (therapeutic use)
• Craniopharyngioma (drug therapy, genetics)
• Humans
• Mutation
• Pituitary Neoplasms (drug therapy, genetics)
• Protein Kinase Inhibitors (therapeutic use)
• Proto-Oncogene Proteins B-raf (genetics)
• beta Catenin (genetics)