Multifunctionality of structural proteins in the enterovirus life cycle.

Abstract

Members of the genus Enterovirus have a significant effect on human health, especially in infants and children. Since the viral genome has limited coding capacity, Enteroviruses subvert a range of cellular processes for viral infection via the interaction of viral proteins and numerous cellular factors. Intriguingly, the capsid-receptor interaction plays a crucial role in viral entry and has significant implications in viral pathogenesis. Moreover, interactions between structural proteins and host factors occur directly or indirectly in multiple steps of viral replication. In this review, we focus on the current understanding of the multifunctionality of structural proteins in the viral life cycle, which may constitute valuable targets for antiviral and therapeutic interventions.

• Authors: Xingjian Wen, Di Sun, Jinlong Guo, Fabian Elgner, Mingshu Wang, Eberhard Hildt, Anchun Cheng
• Journal: Future microbiology (Future Microbiol) Vol. 14 Pg. 1147-1157 (09 2019) ISSN: 1746-0921 [Electronic] England
• PMID: 31368347 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Viral Structural Proteins

Topics

• Enterovirus (growth & development)
• Host-Pathogen Interactions
• Humans
• Viral Structural Proteins (metabolism)
• Virus Internalization
• Virus Replication