Avatrombopag for the treatment of thrombocytopenia in patients with chronic liver disease.

Abstract

Introduction: Thrombocytopenia is a common hematological abnormality in patients with chronic liver disease (CLD), occurring in 64%~84% of patients with cirrhosis or fibrosis. Due to the increased risk of bleeding, thrombocytopenia potentially affects management of CLD, such as surgery or liver biopsy. Avatrombopag is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platelet production. Areas covered: This review summarizes the collected data concerning pharmacokinetics, clinical efficacy, safety and tolerability profiles of avatrombopag for the management of thrombocytopenia in patients with CLD. Expert opinion: Avatrombopag is recently approved by Food and Drug Administration (FDA) for the treatment of thrombocytopenia in patients with CLD who are scheduled to undergo a procedure. Based on the available clinical trials, avatrombopag is superior to placebo in reducing the need for platelet transfusions or rescue procedures for bleeding. Avatrombopag is also recommended as alternative to platelet transfusions.

• Authors: Hongming Xu, Rong Cai
• Journal: Expert review of clinical pharmacology (Expert Rev Clin Pharmacol) Vol. 12 Issue 9 Pg. 859-865 (Sep 2019) ISSN: 1751-2441 [Electronic] England
• PMID: 31352834 (Publication Type: Journal Article, Review)

Chemical References

• Receptors, Thrombopoietin
• Thiazoles
• Thiophenes
• MPL protein, human
• avatrombopag

Topics

• Chronic Disease
• Hemorrhage (etiology, prevention & control)
• Humans
• Liver Cirrhosis (complications)
• Liver Diseases (complications, physiopathology)
• Platelet Transfusion (methods)
• Receptors, Thrombopoietin (agonists)
• Thiazoles (adverse effects, pharmacology, therapeutic use)
• Thiophenes (adverse effects, pharmacology, therapeutic use)
• Thrombocytopenia (drug therapy, etiology)