Abstract | PURPOSE OF REVIEW: Activated protein C (APC) is a homeostatic coagulation protease with anticoagulant and cytoprotective activities. Focusing on APC's effects in the brain, this review discusses three different scenarios that illustrate how APC functions are intimately affecting the physiology and pathophysiology of the brain. RECENT FINDINGS: SUMMARY: APC's many activities or lack thereof are intimately involved in multiple neuropathologies, providing abundant opportunities for translational research.
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Authors | Laurent O Mosnier |
Journal | Current opinion in hematology
(Curr Opin Hematol)
Vol. 26
Issue 5
Pg. 320-330
(09 2019)
ISSN: 1531-7048 [Electronic] United States |
PMID | 31348046
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
- Neuroprotective Agents
- Protein C
|
Topics |
- Humans
- Malaria, Cerebral
(metabolism, therapy)
- Neuroprotection
- Neuroprotective Agents
(metabolism)
- Protein C
(metabolism)
|