Abstract | BACKGROUND:
Asphyxia of newborns is a severe and frequent challenge of the peri- and postnatal period. METHODS: RESULTS: Following AH, systemic elevation of cardiac TnI and HFABP revealed cardiac damage in both groups. Systemic activation of the complement system and the appearance of extracellular histones in plasma of the blood transfusion group were observed. The Cx43 was translocated from the intercalated discs to the cytosol after AH. Cardiac glycogen concentration was reduced in both groups. A significant reduction of C5aR1 in the left ventricle and a significant elevation of the heart injury score were investigated after blood transfusion. CONCLUSION:
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Authors | Birte Weber, Marc Robin Mendler, Ina Lackner, Jochen Pressmar, Melanie Haffner-Luntzer, Severin Höfler, Christian Karl Braun, Helmut Hummler, Stephan Schwarz, Miriam Kalbitz |
Journal | Pediatric research
(Pediatr Res)
Vol. 86
Issue 6
Pg. 709-718
(12 2019)
ISSN: 1530-0447 [Electronic] United States |
PMID | 31336381
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Animals
- Animals, Newborn
- Asphyxia
(complications)
- Echocardiography
- Heart Arrest
(etiology, pathology, physiopathology)
- Hemorrhage
(complications)
- Myocardium
(pathology)
- Swine
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