Abstract | BACKGROUND: MATERIALS AND METHODS: A total of 825 consecutive patients presenting with ischemic symptoms of STEMI >12 hours after symptom onset and undergoing subsequent primary PCI were grouped by time-to-treatment status (≤7 days or >7 days post-MI). Primary endpoints were nonfatal recurrent MI and all-cause mortality. RESULTS: Cumulative rates of recurrent nonfatal MI at 2 years were 4.1% and 3.3% in patients with symptom-onset-to-balloon inflation times of ≤7 days and >7 days, respectively (P = 0.049); and corresponding mortality rates were 3.4% and 4.7% (P = 0.238). In Cox multivariate analyses, syndrome-onset-to-balloon-inflation time was not independently predictive of recurrent MI (P = 0.052) or mortality (P = 0.651) at 2 years, once adjusted for certain clinical and angiographic variables known to influence patient outcomes. The 2-year rate of recurrent MI was highest in patients with multivessel coronary artery diseases undergoing primary PCI ≤7 days after symptom onset to balloon inflation (P = 0.005). CONCLUSIONS: In patients presenting with ischemic signs or symptoms of STEMI >12 hours after initial symptom onset and treated by PCI, symptom-onset-to-balloon-inflation times ≤7 days showed no relation to nonfatal recurrent MI, unless in the presence of multivessel coronary artery diseases.
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Authors | Ming Gao, Ling Qin, Zhiguo Zhang, Liping Chen, Yang Zheng, Qian Tong, Quan Liu |
Journal | The American journal of the medical sciences
(Am J Med Sci)
Vol. 358
Issue 4
Pg. 248-255
(10 2019)
ISSN: 1538-2990 [Electronic] United States |
PMID | 31327461
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved. |
Topics |
- Aged
- Female
- Humans
- Male
- Middle Aged
- Percutaneous Coronary Intervention
- Propensity Score
- Proportional Hazards Models
- ST Elevation Myocardial Infarction
(mortality, therapy)
- Time-to-Treatment
- Treatment Outcome
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