Cystic
ovarian disease in cows was treated either with a single
intramuscular injection of 500 micrograms
cloprostenol, a
prostaglandin F2 alpha analogue, in 77 cases of luteal
cysts or with 500 micrograms
gonadorelin or 20 micrograms
buserelin, gonadotrophin releasing
hormone or its analogue (
GnRH), in 116 cases of
follicular cysts. Recovery was defined as the absence of
cysts and the formation of a corpus luteum either with or without observed oestrus within 10 days
after treatment with
cloprostenol and 15 days
after treatment with
GnRH. Recovery occurred in 65 per cent and 52.6 per cent of cases, respectively, in average times of 4.9 and 19 days. Fifteen days
after treatment with
GnRH, 20 cows with luteinised
cysts were treated with
cloprostenol and 15 recovered in a mean of 20.4 days, while 10 which still had
follicular cysts, were given
GnRH and one recovered 31 days after the beginning of treatment. Another 27 cows, in which
cysts became luteinised, were treated with
cloprostenol seven days
after treatment with
GnRH to give quicker (average 11.5 days) but poor (48 per cent) recovery and with a higher rate (33 per cent) of recurrence of
cysts. A
progesterone releasing intrauterine device was used in 25 cases of cystic
ovarian disease, some of which had been previously treated. Sixty-eight per cent recovered in an average of 15 days. The proportions of cows becoming pregnant to one to three inseminations after the different methods of treatment were similar (77 to 94 per cent).(ABSTRACT TRUNCATED AT 250 WORDS)