Downregulation of matrix Gla protein is a biomarker for tamoxifen-resistant and radioresistant breast cancer.

Abstract

Aim: To establish downregulated biomarkers for cross-resistance for radiotherapy (RT) in tamoxifen (TAM)-resistant breast cancer cells. Materials & methods: RNA sequencing was performed on TAM and RT-resistant breast cancer cells. Breast cancer patient cohorts were queried in silico for associations between genes of interest and outcome after TAM treatment or irradiation. Results: 20 genes showed decreased expression in both TAM-resistant and RT-resistant breast cancer cells. Only matrix Gla protein in the primary tumor was associated with outcome after TAM treatment or RT in breast cancer patients. Conclusion: Matrix Gla protein is a biomarker for therapy sensitivity in breast cancer.

• Authors: Annemarie Em Post, Johan Bussink, Marcel Smid, Fred Cgj Sweep, Paul N Span
• Journal: Biomarkers in medicine (Biomark Med) Vol. 13 Issue 10 Pg. 841-850 (07 2019) ISSN: 1752-0371 [Electronic] England
• PMID: 31317787 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Biomarkers, Tumor
• Calcium-Binding Proteins
• Extracellular Matrix Proteins
• Tamoxifen

Topics

• Antineoplastic Agents, Hormonal (therapeutic use)
• Biomarkers, Tumor (metabolism)
• Breast Neoplasms (drug therapy, mortality, pathology, radiotherapy)
• Calcium-Binding Proteins (genetics, metabolism)
• Databases, Factual
• Down-Regulation
• Drug Resistance, Neoplasm (genetics)
• Extracellular Matrix Proteins (genetics, metabolism)
• Female
• Humans
• Kaplan-Meier Estimate
• MCF-7 Cells
• Radiation, Ionizing
• Tamoxifen (therapeutic use)
• Matrix Gla Protein