Circulating soluble LR11, a differentiation regulator for vascular cells, is increased during pregnancy and exaggerated in patients with pre-eclampsia.

Abstract

BACKGROUND:

Pre-eclampsia is a pregnancy-specific disease characterized by onset of hypertension and proteinuria, sometimes progressing into damaging other organs. Here, we investigated the pathological significance of the soluble fragment of LR11 (sLR11), a cell differentiation regulator, in comparison to circulating IL-6 and TNF-α, in pre-eclampsia.

METHODS:

The study was conducted in a cross-sectional research design with fourteen pre-eclampsia patients and fifty healthy pregnant subjects. Pre-eclampsia was defined as hypertensive disorders in pregnancy at over 20 weeks of gestation with proteinuria.

RESULTS:

Plasma levels of sLR11 as well as IL-6 in pre-eclampsia were increased compared with those in the healthy pregnant subjects at the first, the second, and the third trimester. Receiver operating characteristic analysis for the detection of pre-eclampsia among third-trimester subjects showed that the areas under the curves of sLR11 and IL-6 were equivalent. sLR11 and IL-6 correlated positively with TNF-α in healthy pregnant subjects. In the pre-eclampsia patients, there was neither a correlation between sLR11 and IL-6 nor between sLR11 and TNF-α.

CONCLUSIONS:

sLR11 increases during pregnancy, with levels further exaggerated in pre-eclampsia, and may be related to the pathology of pre-eclampsia.

• Authors: Hiroaki Ishida, Meizi Jiang, Hiroyuki Ebinuma, Nobuyuki Hiruta, Wolfgang J Schneider, Toshihiko Kinoshita, Hideaki Bujo
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 497 Pg. 172-177 (Oct 2019) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 31299181 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• LDL-Receptor Related Proteins
• Membrane Transport Proteins
• SORL1 protein, human

Topics

• Cell Differentiation
• Cross-Sectional Studies
• Endothelial Cells (metabolism, pathology)
• Female
• Humans
• LDL-Receptor Related Proteins (blood, metabolism)
• Membrane Transport Proteins (blood, metabolism)
• Pre-Eclampsia (blood, metabolism, pathology)
• Pregnancy