Prophylactic Antiemetics for Haematological Malignancies: Prospective Nationwide Survey Subset Analysis in Japan.

Abstract

BACKGROUND/AIM:

Although neurokinin-1 receptor antagonists are approved chemotherapy drugs in Japan, no nationwide surveys have been performed to validate chemotherapy-induced nausea and vomiting (CINV) guidelines in clinical practice. This study evaluated CINV in patients with haematological malignancies starting first-time chemotherapy.

PATIENTS AND METHODS:

A nationwide CINV survey on patients with haematological malignancies was conducted at 118 institutions. Patients undergoing moderately emetic chemotherapy (n=17) and highly emetic chemotherapy (HEC; n=180) were compared.

RESULTS:

Forty-one patients undergoing HEC received triple antiemetics. Female gender and young age were risk factors for early-phase nausea, while female gender remained a risk factor for late-phase nausea and vomiting. Among 125 patients receiving CHOP (doxorubicin, cyclophosphamide, vincristine, prednisone)-like regimens, complete response and complete control were increased in patients receiving triple antiemetics, compared to those with double antiemetics.

CONCLUSION:

Guideline compliance was very low. Although not statistically significant, there was a trend for reduced CINV and improved disease control for triple versus double antiemetics, suggesting that triple antiemetics should be considered for HEC, especially in young female patients with non-Hodgkin lymphoma receiving CHOP-like regimens.

• Authors: Isao Yoshida, Kazuo Tamura, Toshihiro Miyamoto, Mototsugu Shimokawa, Yasushi Takamatsu, Yasuhito Nanya, Itaru Matsumura, Moritaka Gotoh, Tadahiko Igarashi, Tsutomu Takahashi, Keisuke Aiba, Kyoya Kumagai, Kenichi Ishizawa, Naoki Kurita, Noriko Usui, Kiyohiko Hatake
• Journal: In vivo (Athens, Greece) (In Vivo) 2019 Jul-Aug Vol. 33 Issue 4 Pg. 1355-1362 ISSN: 1791-7549 [Electronic] Greece
• PMID: 31280230 (Publication Type: Journal Article)
• Copyright: Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Antiemetics

Topics

• Adult
• Aged
• Antiemetics (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Female
• Health Care Surveys
• Hematologic Neoplasms (complications, drug therapy, epidemiology)
• Humans
• Incidence
• Japan (epidemiology)
• Male
• Middle Aged
• Nausea (diagnosis, epidemiology, etiology, prevention & control)
• Premedication
• Severity of Illness Index
• Surveys and Questionnaires
• Treatment Outcome
• Vomiting (diagnosis, epidemiology, etiology, prevention & control)